Congenital Heart Disease – Cardiology, Lecturio
It tends to increase within 3 to 4 hours of myocardial necrosis, then peak in a day and return to normal within 36 datings with heart disease. However, it is not specific for cardiac muscle, and can be elevated with any form of injury to skeletal muscle. BNP release can be stimulated by systolic and diastolic left ventricular dysfunction, acute coronary syndromes, stable coronary heart disease, valvular heart disease, acute and chronic right ventricular failure, and left and right ventricular hypertrophy secondary to arterial or pulmonary hypertension.
BNP is a marker for heart failure. A rapid increase in copeptin can be associated with stroke, sepsis, or acute myocardial injury. In conjunction with troponin, copeptin has high negative predictive value to rule out myocardial injury.